gene_symbol
CEACAM5
hgnc_id
HGNC:1817
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CEACAM5, is internalized, and releases the DM4 (ravtansine) microtubule inhibitor, causing mitotic arrest and apoptosis of the target-expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen targeted by antibody component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05849246
disease_id_num_tar_ref
2683
drug_id_num_tar_ref
7154