gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD19-directed CAR T cells bind CD19 on target B cells, become activated via CD28/CD3ζ signaling, and kill via perforin/granzyme and Fas–FasL apoptotic pathways; orthogonal IL-2 selectively expands the CAR T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen on malignant and normal B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05665062
disease_id_num_tar_ref
2686
drug_id_num_tar_ref
7161