gene_symbol
UNKNOWN
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
STK-009 is a soluble orthogonal IL-2 that activates the engineered hoRb on SYNCAR-001 T cells to expand/persist; killing is directed against CD19+ cells via CAR-mediated cytolytic pathways, not against cells expressing STK-009.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engineered cytokine that selectively binds the hoRb (orthogonal IL-2 receptor beta) expressed on SYNCAR-001; does not bind native IL-2R
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05665062
disease_id_num_tar_ref
2686
drug_id_num_tar_ref
7161