gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its Fc engages FcγRIIIa on NK cells/monocytes to activate ADCC/phagocytosis that kills CD20+ cells. FcγRIIIa-expressing cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Enhanced Fc-mediated ADCC via afucosylated Fc increasing affinity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06504199
disease_id_num_tar_ref
2692
drug_id_num_tar_ref
7174