gene_symbol
GPC3
hgnc_id
HGNC:4451
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-engineered NK cells bind GPC3 on target cells and directly kill them via NK degranulation (perforin/granzyme–mediated cytotoxicity) and related apoptotic pathways; IL-15 supports NK survival/persistence.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
expressed on hepatocellular carcinoma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06652243
disease_id_num_tar_ref
2694
drug_id_num_tar_ref
7181