gene_symbol
IL2RB
hgnc_id
HGNC:6009
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
SN301A CAR-NK cells kill GPC3-positive tumor cells via perforin/granzyme after CAR engagement. CD122 (IL-2Rβ) is engaged by IL-15 to support NK-cell survival and proliferation, not as a cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
forms IL-15 signaling complex with IL15RA and IL2RG on NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06652243
disease_id_num_tar_ref
2694
drug_id_num_tar_ref
7181