gene_symbol
IL2RG
hgnc_id
HGNC:6010
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
SN301A CAR NK cells kill GPC3-positive tumor cells via CAR-triggered perforin/granzyme release. CD132 (common gamma chain) is engaged by IL-15 to support NK-cell survival and is not a cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
forms IL-15 signaling complex with IL15RA and IL2RB on NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06652243
disease_id_num_tar_ref
2694
drug_id_num_tar_ref
7181