gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 CAR T cells bind CD19 on target B cells; CAR signaling triggers a cytolytic synapse and release of perforin/granzymes (and Fas–FasL), inducing apoptosis/lysis of CD19+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell lineage surface antigen on malignant and normal B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06253663
disease_id_num_tar_ref
2697
drug_id_num_tar_ref
7189