gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Ralpha on eosinophils/basophils and engages Fc gamma RIIIa on NK cells to trigger potent ADCC, directly killing IL-5Ralpha+ cells (with additional IL-5 signaling blockade).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Expressed on eosinophils and basophils
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05603845
disease_id_num_tar_ref
2700
drug_id_num_tar_ref
7197