gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets Nectin-4 on the cell surface, is internalized, and releases MMAE, which binds the vinca site on beta-tubulin to inhibit microtubules, causing G2/M arrest and apoptosis. Beta-tubulin is not the recognition target of the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload MMAE binds β-tubulin to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05656235
disease_id_num_tar_ref
2706
drug_id_num_tar_ref
7208