gene_symbol
HLA-C
hgnc_id
HGNC:4933
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine induces neoantigen-specific CD8+ T cells that kill cells presenting the tumor-derived peptide in HLA class I (e.g., HLA-C) via perforin/granzyme or Fas-FasL. HLA-C itself is not the cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Class I peptide presentation on APCs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06314087
disease_id_num_tar_ref
2709
drug_id_num_tar_ref
7215