gene_symbol
HLA-DPB1
hgnc_id
HGNC:4940
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes neoantigen-specific T cells; CD8+ T cells kill tumor cells presenting the neoantigen peptides on MHC, via perforin/granzyme or Fas–FasL. HLA-DPB1 serves as an antigen-presentation molecule and is not itself targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Class II peptide presentation on APCs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06314087
disease_id_num_tar_ref
2709
drug_id_num_tar_ref
7215