gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds TROP-2 (not topoisomerase I); after internalization it releases SN-38, which inhibits topoisomerase I to cause DNA damage and apoptosis. Killing depends on TROP-2-mediated delivery (with possible bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cytotoxic payload SN-38 stabilizes TOP1–DNA complexes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06167317
disease_id_num_tar_ref
2720
drug_id_num_tar_ref
7239