gene_symbol
ITGB2
hgnc_id
HGNC:6155
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Polyclonal antibodies bind CD18 (among other T‑cell antigens) and trigger complement-dependent lysis and Fc receptor–mediated ADCC/phagocytosis, directly depleting CD18+ T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Integrin beta chain; LFA-1 component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05902416
disease_id_num_tar_ref
2727
drug_id_num_tar_ref
7257