gene_symbol
HLA-DRA
hgnc_id
HGNC:4947
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Not targeted. Anti-thymocyte globulin binds T‑cell antigens (e.g., CD2/CD3/CD45) and depletes T cells via complement-dependent lysis and Fc-mediated ADCC/phagocytosis; it does not directly target HLA-DR alpha–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
MHC class II; activation marker on T cells/APCs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05902416
disease_id_num_tar_ref
2727
drug_id_num_tar_ref
7257