gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Irreversible small‑molecule inhibition of mutant EGFR blocks MAPK/PI3K‑AKT signaling, causing apoptosis of EGFR‑mutant tumor cells (minimal effect on wild‑type EGFR).
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
L858R activating mutant; covalent, irreversible ATP-site inhibitor targeting Cys797 in the kinase domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06667076
disease_id_num_tar_ref
2732
drug_id_num_tar_ref
7273