gene_symbol
H3-3A
hgnc_id
HGNC:4764
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the H3.3K27M peptide presented by HLA-A*02:01 and directly kill target cells via perforin/granzyme-mediated cytolysis (with additional cytokine/Fas-FasL apoptotic effects).
enzyme_product
Off
epitope
On
variant
On
isoform
On
hla_specific
On
gated
Off
other_modifier
Peptide–MHC complex target; HLA-A*02:01 restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05478837
disease_id_num_tar_ref
2739
drug_id_num_tar_ref
7292