gene_symbol
TNFRSF13B
hgnc_id
HGNC:18153
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BAFF-ligand CAR-T cells bind TACI on target cells, activating the CAR T cells to release perforin/granzymes and induce apoptotic killing of the TACI-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Ligand-based CAR using BAFF (TNFSF13B) domain; multi-receptor targeting
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05312801
disease_id_num_tar_ref
2751
drug_id_num_tar_ref
7334