gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD30 (not beta-tubulin); after CD30-mediated internalization, MMAE is released and inhibits tubulin polymerization, causing G2/M arrest and apoptosis in CD30-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca domain to inhibit tubulin polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07171827
disease_id_num_tar_ref
2780
drug_id_num_tar_ref
7421