gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Mutant-selective EGFR TKI that irreversibly inhibits EGFR Del19 kinase activity, blocking downstream survival signaling (e.g., PI3K/AKT, MAPK) and inducing apoptosis of EGFR-mutant tumor cells.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Irreversible covalent tyrosine kinase inhibition (binds Cys797); mutant-selective
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05299125
disease_id_num_tar_ref
2793
drug_id_num_tar_ref
7460