gene_symbol
TNFRSF8
hgnc_id
HGNC:11923
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds CD30, is internalized, and releases MMAE via lysosomal cleavage; MMAE inhibits tubulin polymerization, causing G2/M arrest and apoptosis of CD30+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface TNFRSF8 receptor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06563778
disease_id_num_tar_ref
2799
drug_id_num_tar_ref
7482