gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds EGFR/HER3, is internalized, and releases brengitecan; the payload inhibits DNA topoisomerase I, causing DNA damage and cell death (with possible bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload target (brengitecan; camptothecin-class topoisomerase I inhibitor)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06382129
disease_id_num_tar_ref
2807
drug_id_num_tar_ref
7496