gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CD47 on target cells to block the CD47–SIRPα ‘don’t‑eat‑me’ checkpoint and, via its IgG4 Fc, engages Fcγ receptors on macrophages, triggering antibody-dependent cellular phagocytosis and macrophage-mediated killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Sequesters CD47 to block CD47–SIRPα inhibitory signaling and promote macrophage phagocytosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05896774
disease_id_num_tar_ref
2827
drug_id_num_tar_ref
7547