gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the HBV peptide–HLA-A*11:01 complex on tumor cells and kill them via cytotoxic T-cell mechanisms, primarily perforin/granzyme-mediated lysis (and Fas–FasL apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Epitope is presented by HLA-A*11:01 on hepatocellular carcinoma cells (MHC class I–restricted).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06251115
disease_id_num_tar_ref
2828
drug_id_num_tar_ref
7548