gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HLA-A*11:01 expression alone is not sufficient. The engineered TCR-T cells kill only cells presenting the HBV peptide–HLA-A*11:01 complex via TCR engagement, triggering perforin/granzyme-mediated cytolysis.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
TCR recognition is restricted to HBV peptide presented by HLA-A*11:01.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06251115
disease_id_num_tar_ref
2828
drug_id_num_tar_ref
7548