gene_symbol
PDCD1LG2
hgnc_id
HGNC:18731
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CAR T cells kill PSMA-expressing cells via CAR-mediated recognition and perforin/granzyme cytotoxicity. PD-L2 engagement only provides CD28 costimulation through the PD1.CD28 switch receptor and does not make PD-L2+ cells direct cytotoxic targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane ligand; engaged by PD1.CD28 switch receptor to provide CD28 costimulation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06046040
disease_id_num_tar_ref
2830
drug_id_num_tar_ref
7552