gene_symbol
TGFB2
hgnc_id
HGNC:11768
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
These CAR T cells target PSMA, not TGF-β2. They kill PSMA-expressing cells via CAR-mediated T‑cell cytotoxicity (perforin/granzyme). The dominant‑negative TGF‑β receptor only renders the T cells resistant to TGF‑β.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Secreted cytokine; bound by dominant-negative TGF-β receptor to resist suppression
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06046040
disease_id_num_tar_ref
2830
drug_id_num_tar_ref
7552