gene_symbol
TGFB3
hgnc_id
HGNC:11769
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
TGF-beta3 is not the CAR target. The CAR recognizes PSMA and kills PSMA+ cells via T‑cell cytotoxicity (perforin/granzyme). The dominant-negative TGF-beta receptor only blocks TGF-beta signaling in the CAR T cells and does not direct killing of TGF-beta3–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Secreted cytokine; bound by dominant-negative TGF-β receptor to resist suppression
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06046040
disease_id_num_tar_ref
2830
drug_id_num_tar_ref
7552