gene_symbol
CD33
hgnc_id
HGNC:1659
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds CD33, is internalized, and releases calicheamicin that causes DNA double-strand breaks, inhibiting DNA synthesis and inducing apoptosis in the target cell.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Also known as Siglec-3; myeloid differentiation antigen on AML blasts
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05994690
disease_id_num_tar_ref
2839
drug_id_num_tar_ref
7572