gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD33 on target cells, is internalized, and releases calicheamicin, which then binds the DNA minor groove causing double‑strand breaks and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Calicheamicin binds the DNA minor groove and induces double-strand breaks
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05994690
disease_id_num_tar_ref
2839
drug_id_num_tar_ref
7572