gene_symbol
PDGFRA
hgnc_id
HGNC:8803
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ATP-competitive inhibition of PDGFRA kinase blocks downstream survival/proliferation signaling (e.g., MAPK/PI3K), causing growth arrest and apoptosis of PDGFRA-dependent cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06061094
disease_id_num_tar_ref
2865
drug_id_num_tar_ref
7656