gene_symbol
CD33
hgnc_id
HGNC:1659
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD33 antibody-drug conjugate binds CD33, is internalized, and releases calicheamicin that induces DNA double-strand breaks, triggering apoptosis of CD33-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Internalizing myeloid antigen targeted by the antibody component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05558124
disease_id_num_tar_ref
2875
drug_id_num_tar_ref
7703