gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Gemtuzumab ozogamicin targets CD33 on cells, is internalized, then releases calicheamicin that binds the DNA minor groove to cause double-strand breaks and apoptosis; DNA is not the targeted antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Calicheamicin payload binds the minor groove and induces double-strand breaks
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05558124
disease_id_num_tar_ref
2875
drug_id_num_tar_ref
7703