gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Teclistamab binds CD3 on T cells to engage and activate them while simultaneously binding BCMA on myeloma cells; activated T cells kill BCMA+ tumor cells via perforin/granzyme, not the CD3+ T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Part of the T-cell receptor CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05932680
disease_id_num_tar_ref
2890
drug_id_num_tar_ref
7748