gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
T-DM1 binds HER2, is internalized, and lysosomal processing releases a DM1 catabolite that inhibits microtubules, causing mitotic arrest and apoptosis; Fc may also mediate ADCC.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06265428
disease_id_num_tar_ref
2903
drug_id_num_tar_ref
7767