gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody’s Fc binds CD16a on NK cells/macrophages to trigger ADCC/ADCP against HIV Env–expressing infected cells; CD16a-expressing cells are not targeted or killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Mediates ADCC via IgG1 Fc engagement on NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06031272
disease_id_num_tar_ref
2906
drug_id_num_tar_ref
7770