gene_symbol
FCGR2A
hgnc_id
HGNC:3616
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
3BNC117-LS-J binds HIV-1 Env on infected cells; its Fc engages Fcγ receptors (including CD32a) on immune effectors to mediate ADCC/ADCP against Env+ cells. CD32a+ cells are effectors, not targets, and are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Mediates ADCP via IgG1 Fc engagement on myeloid cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06031272
disease_id_num_tar_ref
2906
drug_id_num_tar_ref
7770