gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BCMA-binding CAR on the T cells triggers activation and cytolytic killing of BCMA+ cells via perforin/granzyme release (and death receptor pathways).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane receptor on plasma cells; dual-target CAR (either antigen can trigger activation)
trial_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07139509
disease_id_num_tar_ref
2913
drug_id_num_tar_ref
7784