gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Mesothelin-specific CAR T cells bind mesothelin on target cells and kill them via T-cell cytotoxic mechanisms (perforin/granzyme-mediated apoptosis and Fas–FasL); PD-1 nanobody secretion enhances this activity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR target antigen on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06249256
disease_id_num_tar_ref
2921
drug_id_num_tar_ref
7801