gene_symbol
CD28
hgnc_id
HGNC:1653
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The bispecific binds CD28 on T cells and CD22 on B cells to provide CD28 costimulation, enabling TCR-mediated killing of CD22+ tumor cells. CD28-expressing T cells are not the cells killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell co-stimulatory receptor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05685173
disease_id_num_tar_ref
2923
drug_id_num_tar_ref
7809