gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Irreversible HER2 kinase inhibition blocks HER2 phosphorylation and downstream PI3K/AKT and RAS/RAF/MEK/ERK signaling, leading to growth arrest and apoptotic death of HER2-expressing tumor cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Irreversible inhibitor of the HER2 kinase domain; designed to spare EGFR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06328738
disease_id_num_tar_ref
2925
drug_id_num_tar_ref
7814