gene_symbol
DLL3
hgnc_id
HGNC:2909
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The bispecific T-cell engager binds DLL3 on target cells and CD3 on T cells, forming an immune synapse that activates T cells to kill DLL3-expressing cells via perforin/granzyme-mediated cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Notch pathway ligand on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05990738
disease_id_num_tar_ref
2927
drug_id_num_tar_ref
7823