gene_symbol
FCGR3B
hgnc_id
HGNC:3620
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its afucosylated Fc engages FcγRIIIb (CD16b) on neutrophils to trigger ADCC/phagocytosis against CD20+ B cells. CD16b-expressing cells act as effectors and are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Afucosylated IgG1 Fc increases affinity to Fc gamma RIIIb to support ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06656234
disease_id_num_tar_ref
252
drug_id_num_tar_ref
712