gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug binds CD3E on T cells to engage and activate them against DLL3-expressing tumor cells; T cells then kill DLL3+ cancer cells via perforin/granzyme-mediated cytotoxicity. CD3E+ T cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Epsilon chain of the T-cell receptor CD3 complex on T lymphocytes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05740566
disease_id_num_tar_ref
2936
drug_id_num_tar_ref
7845