gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Osimertinib covalently inhibits mutant EGFR (L858R), suppressing downstream signaling (e.g., MAPK/PI3K pathways) and triggering apoptosis of EGFR-dependent tumor cells.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Irreversible covalent inhibitor; binds Cys797 in the ATP-binding site.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06532149
disease_id_num_tar_ref
2937
drug_id_num_tar_ref
7852