gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CTLA-4 IgG1 binds CTLA-4 on Tregs and, via its Fc engaging Fc receptors on NK cells/macrophages, induces ADCC/ADCP to deplete CTLA-4–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-enhanced IgG1; enables depletion of intratumoral Tregs via Fc-gamma receptor-mediated ADCC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05864534
disease_id_num_tar_ref
253
drug_id_num_tar_ref
714