gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR and its IgG1 Fc engages Fcγ receptors on immune effectors to mediate ADCC (and some CDC), killing EGFR-expressing cells; EGFR blockade can also promote apoptosis.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (ligand-binding site) to block activation/dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06440902
disease_id_num_tar_ref
2944
drug_id_num_tar_ref
7878