gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2, is internalized, and releases MMAE to inhibit tubulin, causing microtubule disruption, G2/M arrest, and apoptosis; IgG1 Fc can also mediate ADCC.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain binding by anti-HER2 IgG1
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06341400
disease_id_num_tar_ref
255
drug_id_num_tar_ref
718