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gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on tumor cells and engages Fcγ receptors on NK cells/other effectors to trigger antibody-dependent cellular cytotoxicity (ADCC), leading to lysis of HER2-expressing cells (with some complement activation possible).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05722886
disease_id_num_tar_ref
2972
drug_id_num_tar_ref
7946