gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and engages Fcγ receptors (e.g., CD16) on NK cells to mediate ADCC, with possible complement-dependent cytotoxicity, killing EGFR+ cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (ECD) domain III; blocks ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06321081
disease_id_num_tar_ref
2975
drug_id_num_tar_ref
7963